Akeelah Anderson (KEKE PALMER) is a bright if unmotivated 11-year-old student at a south Los Angeles middle school. Teased and taunted by other girls for being smart, Akeelah downplays her intelligence and enjoys spending time with her friend Georgia (SARAHA GAREY) when not looking up to her brother Devon (LEE THOMPSON YOUNG) who's training to become a pilot in the Air Force. But her widowed mom, Tanya (ANGELA BASSETT), doesn't have much time for her, what with older sister Kiana (ERICA HUBBARD) having a newborn and teenage sibling Terrence (JULITO McCULLUM) having fallen in with a local gang.
Realizing her potential, Principal Bob Welch (CURTIS ARMSTRONG) encourages Akeelah to enter the school's spelling bee, having planted his longtime friend Dr. Joshua Larabee (LAURENCE FISHBURNE) in the audience. He's a college professor who teaches his courses online, and he immediately tests Akeelah's proficiency, quickly noting her abilities that are far more advanced than her grade level.
While both are somewhat initially reluctant to work with each other, they eventually come to an agreement where he'll serve as her spelling bee mentor as long as she follows his strict rules. Despite some bumps in the road, her skill increases, eventually leading to more prominent competitions where she meets the likes of friendly Javier (J.R. VILLARREAL), who shows her the ropes, and the far more serious and uptight Dylan (SEAN MICHAEL) whose single-minded and stern father, Mr. Chiu (TZI MA), wants nothing but complete success from his son.
As Joshua must deal with his own personal issues, he pushes Akeelah -- who now has the growing support of her community behind her -- to be the best that she can, all as she hopes to make it to the national championship bee.