It's 1953 and Edward R. Murrow (DAVID STRATHAIRN) is the New York City based host of CBS News' "See it Now" and "Person to Person." Along with his producer Fred Friendly (GEORGE CLOONEY) and hard working staff that includes Don Hewitt (GRANT HESLOV), Palmer Williams (TOM MCCARTHY), Jesse Zousmer (TATE DONOVAN), John Aaron (REED DIAMOND), Charlie Mack (ROBERT JOHN BURKE), Eddie Scott (MATT ROSS) and Joe (ROBERT DOWNEY JR.) and Shirley Wershba (PATRICIA CLARKSON) -- who've kept their marriage secret although most everyone knows - Murrow reports on daily newsworthy stories to the American people.
His focus of recent has been on Republican U.S. Senator Joseph McCarthy of Wisconsin whose efforts to root out communists and their sympathizers have made him one of the most feared men in the country. That's especially true for members of the press -- such as Murrow protégé Don Hollenbeck (RAY WISE) -- who are pointed out as being communists if they question his tactics or targets.
But when Navy pilot Milo Radulovich is kicked out of the military for refusing to denounce his immigrant father and sister for their alleged suspicious activity, Murrow feels it's his duty to expose McCarthy and his questionable tactics. That worries CBS' number two man Sig Mickelson (JEFF DANIELS) who's concerned about the potential ramifications, and eventually draws the attention of his boss, William Paley (FRANK LANGELLA) who reluctantly agrees to let Murrow and his crew continue with their reporting.
As the months pass and McCarthy turns up the heat on Murrow, the show, CBS and their corporate sponsor, the newsman and his crew continue to strive to inform the American public about McCarthy's activities, in hopes that they might be able to make a change.