After winning $100 million in a court case against an airline, unsuccessful entrepreneur Nashawn Wade (KEVIN HART) suddenly decides that he's going to open the world's first black-themed airline. With the help of his cousin Muggsy (METHOD MAN) who hires laidback pilot Captain Mack (SNOOP DOGG) and his more uptight African co-pilot, Gaeman (GODFREY), as well as flight attendants Blanca (SOFIA VERGARA), Flame (GARY ANTHONY WILLIAMS) and Tamika (ANGELL CONWELL), and bathroom attendant Johnny (D.L. HUGHLEY), the group prepares for their inaugural flight.
Among their passengers is Mr. Hunkee (TOM ARNOLD), his girlfriend Barbara (MISSI PYLE) and his two kids Heather (ARIELLE KEBBEL) and Billy (RYAN PINKSTON), who comprise the only white people on board. Then there's amorous couple Cherry (SOMMORE) and DJ (BRIAN HOOKS) who want to have sex everywhere in the plane, and security guard Jamiqua (MO'NIQUE) who earlier frisked well-endowed model Jerome (DWAYNE ADWAY). Also on board is an older blind man (JOHN WITHERSPOON) who claims to be a player, as well as Giselle (K.D. AUBERT), Nashawn's ex-girlfriend.
With plenty of black themed amenities for both the upper and lower class passengers, the plane lifts off on its inaugural flight and the partying and assorted shenanigans soon begin.