It's Thanksgiving in Los Angeles and everyone's getting ready for the holiday, whether it's preparing for the big feast or arriving back home from out of town. Among those getting ready is the Williams family where mother Audrey (ALFRE WOODARD) is hoping for a perfect celebration. Unfortunately, she must cope with her meddling and critical mother-in-law, Grace (ANN WELDON), as well as her always busy at work husband, Ronald (DENNIS HAYSBERT), and his estranged relationship with their college-aged son,
Michael (ERIC K. GEORGE), who may or may not come home for the holidays.
Then there's the Avila family where mother Elizabeth (MERCEDES RUEHL) hopes to introduce her new boyfriend and fellow teacher, Daniel (A MARTINEZ), to the family, but must contend with the fact that her son, Anthony (DOUGLAS SPAIN) has invited her adulterous and now separated husband, Javier (VICTOR RIVERS), over for Thanksgiving in hopes of getting them back together.
Although most of her family wants that to occur, Elizabeth needn't worry about getting such pressure from her daughter, Gina (ISIDRA VEGA), since she's preoccupied with her college boyfriend, Jimmy Nguyen (WILL YUN LEE), who's meeting the Avilas for the first time.
He's told his Vietnamese family that he can't get away from college, a point that only further upsets his mother, Trinh (JOAN CHEN), who doesn't understand where she went wrong in raising her kids. Among them is Jenny (KRISTY WU) who's adopted the American culture wholeheartedly but upset the family upon their discovery of a condom among her belongings, while her brother, Gary (JIMMY PHAM), has been hiding a gun under his bed.
Meanwhile, over at the Seelig household, parents Ruth (LAINIE KAZAN) and Herb (MAURY CHAYKIN) are trying to cope with the pairing of their adult daughter, Rachel (KYRA SEDGWICK) and her longtime lesbian lover, Carla (JULIANNA MARGULIES), and hope to keep that relationship secret from other visiting family members. As the various families assemble and then prepare and consume their Thanksgiving feasts, they all must then deal with the various family concerns and issues that arise over the holiday.