Parker (RYAN PHILLIPPE) and Longbaugh (BENICIO DEL TORO) are longtime criminal partners who've grown tired of "making a living" through petty crime, contract hits and even the occasional sperm donation. It's during the latter when they overhear information that will be the catalyst for their potentially most lucrative crime yet.
It seems that a certain young woman, Robin (JULIETTE LEWIS), have agreed to be the surrogate mother for a well-to-do Southwestern "businessman," Hale Chidduck (SCOTT WILSON), and his younger trophy wife, Francesca (KRISTIN LEHMAN).
Being the opportunists they are, Parker and Longbaugh figure they can kidnap Robin and demand a hefty ransom. After a violent gun battle with two of Chidduck's bodyguards, Jeffers (TAYE DIGGS) and Obecks (NICKY KATT), they do just that. Yet, when they call in Robins' obstetrician, Dr. Allen Painter (DYLAN KUSSMAN), they learn the harsh reality of their situation.
It turns out that Chidduck is a ruthless and powerful criminal himself, a man with enough money and connections to get anything he wants done. As such, he assigns Joe Sarno (JAMES CAAN), a professional and highly efficient "bag man," to take care of the problem and leave no loose ends.
With Parker and Longbaugh taking Robin to a remote Mexican town, Sarno and his longtime associate, Abner (GEOGGREY LEWIS), set out to find the kidnapers and resolve the situation. With the various involved parties jockeying to gain the upper hand, it soon becomes evident that everyone's intentions aren't what they seem, all of which leads to a dramatic and violent conclusion.