In the separate worlds of FBI trainee Clarice Starling (JODIE FOSTER) and psychiatrist/cannibal Hannibal Lecter (ANTHONY HOPKINS), there are vastly different intentions. Clarice must contend with basically working in what looks like a man's world amidst the FBI Academy, evidenced by the looks she gets, those who try to pick up on her, and especially her superior, Jack Crawford (SCOTT GLENN), who sends her out to visit with Lecter on a most urgent quest.
That's to glean enough information from him that will help the Bureau track down a notorious serial killer named Buffalo Bill (TED LEVINE), who kidnaps women, keeps them alive for a few days, then kills and skins them. His apparent next victim, Catherine Martin (BROOKE SMITH), is a Tennessee senator's daughter, and thus the situation becomes much more desperate to find this twisted man.
Dr. Lecter, on the other hand, has been imprisoned in a solitary cell for the past 8 years, known very well for cooking various friends and serving them to those who joined him for dinners at his home. When Clarice comes calling to his cell, he sees it as an opportunity to play a little, to toy with the mind of this burgeoning FBI agent, who has a lot in her past that she would rather keep locked away, but which Lecter takes pleasure in forcing her to dredge up in exchange for badly needed information.
As it's believed that time is running out, deals are hastily made, investigations become more intense, and the search is on for the senator's daughter, to remove her from the clutches of her captor.