Milo Boyd (GERARD BUTLER) is a former cop who has spent the previous few years as a bounty hunter. To Milo's delight, his boss (JEFF GARLIN) gives him the assignment to track down his ex-wife, Nicole (JENNIFER ANISTON), an investigative reporter who has skipped bail to continue her investigation into a possible homicide made to look like a suicide that may or may not involve her cop friend, Bobby (DORIAN MISSICK).
It doesn't take long for Milo to figure out where Nicole is after picking the brain of his former mother-in-law, Kitty (CHRISTINE BARANSKI). Milo, though, is tasked with driving Nicole back from Atlantic City to New York City all the while the two are at each other's throats for everything that went wrong with their marriage. At the same time, the real criminal, Mahler (PETER GREENE) behind the story Nicole is working on is also on her trail after abducting her main source, Jimmy (ADAM ROSE). Meanwhile, Stewart (JASON SUDEIKIS) a nerdy coworker of Nicole's doesn't take no for answer and follows her as best he can from place to place hoping to win her love.
Milo, a gambling addict, has people after him, too, for the debts he has rung up. As he and Nicole get chased, shot at, and continually harassed, the two begin to draw closer again. Soon, they find themselves teaming up to get to the bottom of Nicole's story.