Long ago, a woman known as Mother Gothel (voice of DONNA MURPHY) came upon a flower with magical powers including the ability to heal and keep one forever young in appearance. Thus, she wasn't happy when the local king sent out his people to find the flower to heal his ailing, pregnant wife, the queen. She survived, their baby was born, and in a fit of jealousy, Mother Gothel broken into the palace and kidnapped the infant to raise her as her own.
Now, nearly 18 years later, Rapunzel (voice of MANDY MOORE) is a striking beauty, with unbelievably long hair that, accompanied by her singing, keeps Mother Gothel young. Of course, no one else has ever seen Rapunzel as Mother Gothel keeps her locked away in a remote and tall tower, constantly reminding her of how dangerous it is out in the real world. With the tower door sealed shut, the only way in and out for Mother Gothel is via Rapunzel lowering or hoisting her up with her hair, meaning the young woman's only friend is her chameleon, Pascal.
Little does she know she's about to get a new visitor in the form of Flynn Ryder (voice of ZACHARY LEVI). He's a dashing young man who's recently stolen a valuable crown from the palace with the aid of the thuggish Stabbington Brothers (voices of RON PERLMAN), and is now on the run not only from them and a headstrong guard horse, Maximus, but also the armed palace guards.
Spotting Rapunzel's tower, he climbs his way to what he thinks is safety, only to be knocked out by her, all while Mother Gothel is away. Having hidden his stolen crown, she only agrees to give it back if he takes her to the palace to see the annual lighting and ascension of the lanterns. Unbeknownst to her, it's something the still heartbroken King and Queen do each year on her birthday, hoping it will signal her to come back.
Now teamed with Maximus, Flynn and Rapunzel set off to hold up their respective ends of the deal, but they must contend with the palace guards, the Stabbington Brothers and now Mother Gothel coming after them.