John Crowley (BRENDAN FRASER) is a marketing executive at a major pharmaceutical company in Portland that ironically doesn't manufacture a drug that might save the lives of two of his kids. Then again, no cure or even life sustaining drug currently exists for those suffering from Pompe Disease, a form of Muscular Dystrophy that results in eventual loss of muscle control and dangerous enlargement of various body organs. Worse yet, it only afflicts the young, with an expected lifespan of only nine years or so.
Accordingly, John, his wife, Aileen (KERI RUSSELL), and their oldest son, John Jr. (SAM M. HALL) who doesn't have the genetic disease, can only watch as the conditions of 8-year-old Megan (MEREDITH DROEGER) and 6-year-old Patrick (DIEGO VELAZQUEZ) progressively deteriorate. But there's a glimmer of hope in the medical research work being done by Dr. Robert Stonehill (HARRISON FORD) who's been researching the disorder for the past 10 years at the University of Nebraska.
Brilliant but a bit eccentric and possessing a short-fuse and disdain for being interrupted, Robert hasn't returned any of Brendan's calls. When Megan nearly dies from her worsening condition, John drops everything, travels to Nebraska, and convinces Robert to help him. But the two need a lot of money to take the promising drug from concept to marketable product, and thus scramble for venture funding and finally agree to a deal with a larger firm run by Erich Loring (PATRICK BAUCHAU).
Yet, as John clashes with their immediate supervisor, Dr. Kent Webber (JARED HARRIS), and Robert with nearly everyone else, time and a number of bureaucratic obstacles threaten their efforts and thus the lives of John and Aileen's youngest kids.