Leigh Anne Touhy (SANDRA BULLOCK) is a confident woman with a profitable business as a home designer, a good husband in restaurateur Sean (TIM McGRAW), and proud mother to teen Collins (LILY COLLINS) and her younger and quite precocious brother, S.J. (JAE HEAD). She's used to getting what she wants, but does so with a heaping of southern charm that prevents others from harboring any bad feelings toward her.
When she sees teenager Michael Oher (QUINTON AARON) walking along in the cold without proper attire, and not only learns that he attends the same Christian school where S.J. is a student, but has also been sleeping in the gym there due to his mom being a drug addict, Leigh Anne decides without hesitation that he should stay with them.
She isn't the only one interested in him, however, as Coach Cotton (RAY McKINNON) realizes the teen's immense size could come in quite handy on the football team. The only problems are Michael knows little about how to play the game, is perhaps too passive in training, and doesn't have the grades or reading ability to be on the squad.
Even so, and with both the Touhys and various teachers' help, Michael progresses both in the classroom and on the field, eventually drawing the attention of college recruiters. With his grades needing more help, however, Leigh Anne hires tutor Miss Sue (KATHY BATES) to get him ready for college, but they must all contend with several obstacles that threaten to undermine their work and his future potential.