Thanks to the pioneering research work done by scientist Lionel Canter (JAMES CROMWELL), most people now experience the world through and are represented by more perfect, robotic surrogates of themselves. Controlled by neurological connections when the users are positioned in stem chairs, the surrogates, built by the VSI corporation, do most of the work while also allowing their owners to live out fantasies or simply escape the realities of their lives.
Maggie Greer (ROSAMUND PIKE) is one of those people, as she escapes into her alternate persona as a way of dealing with the loss of her son, while her FBI agent husband, Tom (BRUCE WILLIS), immerses himself in his work alongside his agency partner, Jennifer Peters (RADHA MITCHELL). They normally don't have much to do, what with crime and other social ills nearly absent from everyday life, but that changes when a hitman, Miles Strickland (JACK NOSEWORTHY), kills a surrogate, resulting in the death of the user.
Not only has that never occurred before, but the victim just so happens to be the son of Canter who was fired from his company years earlier and no longer is a fan of their work. The same holds true for groups of human protestors led by The Prophet (VING RHAMES) who believes surrogates are an abomination. With all of that potentially involved, and with the aid of human network controller Bobby (DEVIN RATRAY), the FBI agents start their investigation under the supervision of their boss, Andrew Stone (BORIS KODJOE).
But when Tom breaks the rules while pursuing Strickland and ends up losing his surrogate, he's suspended. From that point on, he must then go out into the real world for himself as he tries to get to the bottom of what's really occurring, all while hoping to reconnect with his estranged and emotionally distant wife.