Begun by Nazi experiments in WWII attempting to achieve a perfect human weapon and then continued on by various governments over the following decades, a number of people consequently possess paranormal powers. Among them is Nick Grant (CHRIS EVANS), a second-generation "mover" who can manipulate things via telekinesis. Having fled to Hong Kong following the murder of his father a decade earlier by U.S. Government "Division" leader Henry Carver (DJIMON HOUNSOU), Nick is an American expatriate flying below the radar, trying to make money by manipulating dice games with his mind.
Unfortunately, his control isn't perfected yet, but he has bigger worries when some government agents come looking for him, followed by the arrival of 13-year-old Cassie Holmes (DAKOTA FANNING). She's a "watcher" who can see into the future via her clairvoyance, although her visions -- that she continuously sketches on paper -- don't always make sense.
Nevertheless, she's come to him since some involve them, a missing briefcase, and a telepathic "pusher," Kira Hudson (CAMILLA BELLE), who can put any sort of thought into another person's mind. She's the only one of their kind who's survived an experimental injection by Carver -- who's also a pusher -- designed to create a super enhanced version of their powers.
It turns out she's also Nick's former girlfriend, and Carver isn't the only one after her and the missing syringe of that experimental serum. There's also an Asian syndicate that's using watcher Pop Girl (LU LU) as well as some men known as "bleeders" -- who emit pain-inducing sonic frequencies -- to try to find her. After "stitcher" Teresa Stowe (MAGGIE SIFF) heals Nick following an encounter with them, he, Cassie and Kira go on the run.
With the help of Hook Waters (CLIFF CURTIS), a "shifter" who can create temporary visual illusions, "sniff" Emily Hu (MING-NA), a clairvoyant who uses her highly tuned olfactory senses to "see" things, and Pinky Stein (NATE MOONEY), a "shadow" who can obscure people from other clairvoyants as long as he's in close proximity to the person he's shielding, the unlikely trio tries to avoid those after them. That includes Carver's right-hand man and incredibly strong mover, Victor Budarin (NEIL JACKSON), all as they hope to use the coveted, serum-filled syringe to ensure the release of Cassie's long-held watcher mother.