It's 1944 and Lt. Aldo Raine (BRAD PITT) and his small team of Jewish Americans -- a.k.a. the "inglourious basterds" -- have been making the lives of Nazis in France so miserable, what with scalping their victims and carving swastikas into the foreheads of those they let go, that Adolf Hitler (MARTIN WUTTKE) wants all of them captured and killed. But Aldo and his men, including Cpl. Wilhelm Wicki (GEDEON BURKHARD), Nazi turncoat Sgt. Hugo Stiglitz (TIL SCHWEIGER) and Sgt. Donny "The Bear Jew" Donowitz (ELI ROTH) -- best known for his baseball bat wielding ways -- have smartly avoided detection so far.
Their latest mission is to assist with a covert operation to assassinate Hitler at a screening of "Nation's Pride," the latest propaganda film from Joseph Goebbels (SYLVESTER GROTH). His star, real life German military hero Frederich Zoller (DANIEL BRÜHL), who plays himself in the pic, has become so smitten with a young French woman, Emmanuelle (MÉLANIE LAURENT), that he convinces Goebbels to have his premiere at the local theater she runs with her projectionist, Marcel (JACKY IDO).
Little do any of them know that her real name is Shosanna Dreyfus or that her entire family was murdered by German Colonel Hans Landa (CHRISTOPH WALTZ) years earlier. Notoriously known as "The Jew Hunter," Landa is quite good at ferreting out and killing the remaining Jews in France, and Shosanna is shocked when she ends up meeting him again through Zoller. Learning that he, Goebbels and even Hitler himself will be at the film premiere, she sets out to get her revenge.
But she's not the only one aiming to take advantage of the surprising collection of despised Nazis, as British intelligence officer Lt. Archie Hicox (MICHAEL FASSBENDER) is meeting German actress turned Allies conspirator, Bridget Von Hammersmark (DIANE KRUGER), to get into the screening. With Aldo and his men ready to assist them, the stage seems set for a strike that might put an end to the war, but they must contend with unexpected developments as well as Landa's ability to sniff out the enemy.