Paul (HUGH GRANT) and Meryl Morgan (SARAH JESSICA PARKER) are so successful in their careers in New York City -- he's a lawyer while she runs her own real estate firm -- that they require personal assistants -- Adam (JESSE LIEBMAN) for him and Jackie (ELISABETH MOSS) for her -- just to make it through the day. Yet, they've now been separated for three months due to him cheating on her, a mistake for which he wants to make amends.
While out for the evening, they happen to witness a murder committed by Vincent (MICHAEL KELLY), a hitman working for an international arms dealer. The Feds realize the couple will likely now be targets themselves, and thus put them into the witness relocation program, eventually depositing them just outside a small town in Wyoming.
There, and with new last names, they end up staying with U.S. Marshal and local sheriff Clay Wheeler (SAM ELLIOT) along with his gun-toting wife, Emma (MARY STEENBURGEN), with Meryl pretending to be Clay's cousin from Chicago. As they get used to the remote living -- including the presence of grizzly bears -- and small town life -- where Doc Simmons (DAVID CALL) and Nurse Kelly (KIM SHAW) are the only medical practitioners and the owner of the lone restaurant, Earl Granger (WILFORD BRIMLEY), has already indoctrinated his granddaughter, Lucy (GRACIE BEA LAWRENCE), into being suspicious of big city folk -- the Morgans must also contend with being stuck together.
As they await their new, separate relocations, their relationship continues to change, all as Vincent tries to figure out where they've been sent, find them, and put an end to their lives as protected witnesses.