Burt Farlander (JOHN KRASINSKI) and Verona De Tessant (MAYA RUDOLPH) are an unmarried couple who are expecting their first child together. When they learn that his parents -- Jerry (JEFF DANIELS) and Gloria (CATHERINE O'HARA) -- are moving to Antwerp for two years, they realize they're no longer tethered to their current locale and can choose where they'll next live and raise their child.
Accordingly, they decide to travel to a number of places, starting with Phoenix where they visit Lily (ALLISON JANNEY) and Lowell (JIM GAFFIGAN), but realize that Verona's former coworker is an awful parent. That's followed a trip to Tucson to see Verona's sister, Grace (CARMEN EJOGO), after which they visit Burt's unofficial "cousin," LN (MAGGIE GYLLENHAAL), a new age professor he's known since they were kids, and who's living with the like-minded Roderick (JOSH HAMILTON).
They eventually head off to Montreal where they stay with Verona's college roommate, Munch Garnett (MELANIE LYNSKEY), her husband, Tom Garnett (CHRIS MESSINA), and that couple's happy, adopted kids, and eventually head down to Miami to see Burt's brother, Courtney (PAUL SCHNEIDER), whose wife has left him and their young daughter. Yet, for all of their traveling, Burt and Verona realize that appearances can be deceiving and that they must chose their own path for their family.