Adam Raki (HUGH DANCY) is a 29-year-old man who now lives alone in a large apartment in Manhattan following the death of his father. An electronics engineer, Adam has Asperger's Syndrome, a high functioning level of autism that makes him uncomfortable with most non work or science related social settings, and his only real friend is Harlan (FRANKIE FAISON) who served in the military with Adam's dad.
Things change for Adam when Beth Buchwald (ROSE BYRNE) becomes his new upstairs neighbor. A schoolteacher and aspiring children's book author, she initially isn't sure what to make of Adam and his somewhat unusual demeanor and behavior, but he quickly grows on her and the two eventually become an item. That doesn't sit well with Beth's dad, Marty (PETER GALLAGHER), an opinionated accountant who's now facing an indictment, a development that's shocked Beth and her mom, Rebecca (AMY IRVING).
From that point on, Beth tries to decide out what's right for herself and her relationship with Adam, all while hoping to figure out how best to communicate with him and his unique way of viewing himself, the world, and others.