Rex Brooks (SIGOURNEY WEAVER) is a TV director for Global Network News, a channel providing coverage of a world anti-terrorism summit being held in Salamanca, Spain. With reporter Angie Jones (ZOE SALDANA) reporting live from the event that's taking place at an outdoor plaza, Rex wants to make sure they have all of the story's angles covered.
The same holds true for Secret Service agents such as Kent Taylor (MATTHEW FOX) who needs to make sure no harm will come to U.S. President Ashton (WILLIAM HURT), one of the key summit speakers, who must decide whether to follow the hawkish advice from one of his top advisors, Phil McCullough (BRUCE McGILL).
The one wild card in play is Secret Service agent Thomas Barnes (DENNIS QUAID) who hasn't been quite right since taking a bullet for Ashton in the past, but is returning to active duty with this assignment. Nervously scanning the crowd and surroundings for anything out of the ordinary, Thomas watches American tourist Howard Lewis (FORREST WHITAKER) who's videotaping the event, but seems most interested in where the agent is looking.
Then the unthinkable occurs. Ashton is shot twice, followed by chaos and then a huge explosion in the plaza. And then the film rewinds to show the events leading up to the assassination attempt as seen through the eyes of various people there, including Thomas, Howard, local cop Enrique (EDUARDO NORIEGA), former special forces operative Javier (EDGAR RAMIREZ), and terrorists Suarez (SAID TAGHMAOUI) and Veronica (AYELET ZURER).
As the event unfolds again and again, we see Thomas and others trying to figure out who's responsible and attempting to capture them.