It's been several years since we last saw New York friends Carrie Bradshaw (SARAH JESSICA PARKER), Samantha Jones (KIM CATTRALL), Charlotte York (KRISTIN DAVIS) and Miranda Hobbes (CYNTHIA NIXON), and they've all moved along in their personal and romantic lives.
For Brooklyn lawyer Miranda, that means balancing work with raising her son with husband Steve Brady (DAVID EIGENBERG). Charlotte is happily married to Harry Goldenblatt (EVAN HANDLER) and enjoying their adopted daughter, while Samantha is living in Los Angeles managing the career of her model boyfriend, Jerry "Smith" Jerrod (JASON LEWIS). And after having landed financier John James Preston, a.k.a. "Mr. Big" (CHRIS NOTH) for what appears to be the final time, Carrie is preparing to move into a new place with him.
The two eventually decide to get married, alternatively shocking and pleasing her close friends, but with their blessings and the help of friends Anthony Marentino (MARIO CANTONE) and Stanford Blatch (WILLIE GARSON), the preparations get under way.
But when things go awry, Carrie ends up in a funk, eventually hiring personal assistant Louise (JENNIFER HUDSON) to help sort out her belongings and life. From an unexpected pregnancy to infidelity and the temptation of a sexually active neighbor, Dante (GILLES MARINI), Carrie and her friends must then deal with their respective disappointments, surprises, insecurities, and the effect all of that has on their friendships.