Adrienne Willis (DIANE LANE) is a former artist turned housewife and mother to moody teenager Amanda (MAE WHITMAN) and her 10-year-old brother Danny (CHARLIE TAHAN). Adrienne has faced several setbacks in the past year, most notably the death of her father, as well as her husband, Jack (CHRISTOPHER MELONI), moving out and leaving her for another woman.
Now, just as Adrienne is headed for the coastal town of Rodanthe, North Carolina to run an inn for her friend Jean (VIOLA DAVIS) who's going on vacation, Jack informs Adrienne that he made a mistake and wants to move back home. She tells him she'll think about it and then sets out for the shore where she meets the inn's lone guest, Dr. Paul Flanner (RICHARD GERE), a surgeon from Raleigh.
Before heading overseas to find and return his estranged adult doctor son, Mark (JAMES FRANCO), Paul has arrived in Rodanthe to meet Robert Torrelson (SCOTT GLENN), the husband of one of his patients who died during surgery. As he tries to deal with that and all of its repercussions, and Adrienne tries to figure out what to do with her marriage, the two end up befriending and eventually falling for each other.