It's the year 2012 and private corporations have taken over the country's prisons, turning them into for-profit entities, mainly through the form of pay-per-view televised gladiator style fights. Yet, the public has become bored with that, and thus Warden Hennessey (JOAN ALLEN) has concocted the three-day, three-stage Death Race on the Terminal Island Penitentiary grounds.
In it, hand-picked prisoners drive heavily armed and armored cars on a closed-course where Hennessey or her head guard, Ulrich (JASON CLARKE), can deactivate any of the weapons at their discretion, all to boost ratings and thus paying public subscribers to their offering. There's only one problem, however, as the most popular driver, the masked Frankenstein, died in the last race against his chief rival, Machine Gun Joe (TYRESE GIBSON).
Of course, his demise has been kept secret, but Hennessey has a backup plan and driver in mind. He's unemployed steel mill worker -- and former race car driver -- Jensen Ames (JASON STATHAM) who, along with his wife, is attacked by a masked man and then framed for her murder. Now imprisoned on Terminal Island, Jensen gets an offer from Hennessey: Pretend to be Frankenstein, and if he wins that character's fifth such race, he'll earn his freedom. But if he tries to blow the whistle on this subterfuge, he'll never see his infant daughter again.
Jensen reluctantly agrees and is paired with Frankenstein's pit crew, prison veteran Coach (IAN McSHANE) and grease monkeys Gunner (JACOB VARGAS) and Lists (FREDERICK KOEHLER), as well as Case (NATALIE MARTINEZ), his sexy, shotgun-riding navigator.
From that point on and after realizing he was set up by Hennessey, Jensen does what he can to get his revenge, all while having to contend with driving against the likes of Pachenko (MAX RYAN), Travis Colt (JUSTIN MADER), Grimm (ROBERT LaSARDO) and 14K (ROBIN SHOU), not to mention Machine Gun Joe who's figuratively and literally gunning to defeat him.