Dr. Jack Gramm (AL PACINO) is a forensic psychologist and professor at a college in Seattle who's best known for his courtroom testimony that helped convict Jon Forster (NEAL McDONOUGH) as the city's notorious Seattle Slayer. Forster has always claimed he's innocent, and that's returned to top the news now that it's the eve of his scheduled state execution. Of particular note is that similar rape-murders have started occurring again, casting doubt for many about the conviction as well as Jack's testimony.
While his personal assistant, Shelly Barnes (AMY BRENNEMAN), student teaching assistant Kim Cummings (ALICIA WITT) and FBI Special Agent Frank Parks (WILLIAM FORSYTHE) believe in him, some of his students, such as Lauren Douglas (LEELEE SOBIESKI) and Mike Stempt (BENJAMIN McKENZIE) question his modus operandi, especially when he picks up strangers at bars such as Sara Pollard (LEAH CAIMS), points not lost on school dean Carol Johnson (DEBORAH KARA UNGER).
Things become more complicated when one of Jack's students ends up as the latest victim of the real or copycat slayer, causing the feds to cast a suspicious eye on him since he was out with her and other students the night of her death. It gets even worse for Jack when he receives an anonymous telephone call informing him that he has just 88 minutes to live.
He initially thinks it's a prank, but as the calls keep coming, each progressively announcing less time for him, Jack tries to figure out who's responsible. While Kim thinks it might be her jealous ex, Guy LaForge (STEPHEN MOYER), Jack knows the calls are somehow tied back to Forster. From that point on, and as it looks like someone's trying to frame him for the murders, Jack races against time to solve the mystery before it's too late for him and/or others.