After a bombing in North Africa kills a CIA case officer, young analyst Douglas Freeman (JAKE GYLLENHAAL), who was there at the attack, finds himself overseeing the interrogation of suspected terrorist Anwar El-Ibrahimi (OMAR METWALLY). He's an Egyptian born chemical engineer who's lived in the U.S. since he was 14, and is now married to the very pregnant Isabella (REESE WITHERSPOON).
She's concerned when he doesn't return from a business trip to Cape Town, and after she can't get answers from anyone, she turns to her former college boyfriend, Alan Smith (PETER SARSGAARD), who works for U.S. Senator Hawkins (ALAN ARKIN). Alan starts doing a little digging, but runs into major resistance from a high-ranking CIA official, Corrine Whitman (MERYL STREEP), when he starts asking about extraordinary rendition, a procedure where the U.S. can hold suspected terrorists in overseas facilities without due legal process.
Corrine won't admit nor deny anything to do with Anwar, meaning the engineer must face the torturous interrogation techniques delivered by Abasi Fawal (IGAL NAOR). Unbeknownst to him, his rebellious daughter, Fatima (ZINEB OUKACH), is secretly seeing fellow student Khalid (MOA KHOUAS), who's been drawn into the terrorist movement.
As Isabella and Alan try to use the available resources to find out what happened to Anwar, Douglas questions whether the torture he witnesses is justified, all while wondering if Anwar really is involved with the terrorists, unaware that the likes of Khalid are preparing for the next strike.