It's the late 21st century, and a military-based virus that was supposed to have created super-soldiers has instead infected common, everyday people. At first, the victims -- known as hemophages -- were shunned and made to wear identifying armbands. Later, they were shipped away to camps and then pretty much disappeared from sight. And now the government, led by Daxus (NICK CHINLUND), wants to eradicate the remaining ones, and his people have devised a weapon they believe will do the trick.
Little do they know, however, that the courier who's arrived to transport it is one of their targets. Once a wife and expectant mother who lost both her husband and pregnancy, Violet (MILLA JOVOVICH) is now a force to be reckoned with. Proficient at martial arts, able to partially neutralize gravity and possessing the ability to literally pull a bevy of weapons out of nowhere, Violet is Daxus' worst nightmare, and she hopes that whatever's in the case she now possesses might somehow lead to a cure.
But when she opens it up to take a look, she discovers a boy, known only as Six (CAMERON BRIGHT), rather than a weapon. With her survival and maternal instincts kicking in, Violet manages to get the boy out of the government complex and takes him to rogue scientist Garth (WILLIAM FICHTNER). Like Violet, he's one of the vampire-like Hemophages, but he has bad news for Violet. Not only does the boy not possess any sort of remedy for them, but also he's going to die within a number of hours.
With time running out, Violet does what she can for the boy and tries to prevent him from falling back into Daxus' hands, all while battling the leader's various minions as well as some of her own who have their own reason for wanting the boy.