It's the 1700s and Tristram Shandy (STEVE COOGAN) is a proper English gentlemen who's addressing the viewer about his life and times, including that of his Uncle Toby (ROB BRYDON) who suffered an embarrassing injury in the siege of Namur. But Tristram is most interested in talking about his own birth. We then flashback to his father Walter (STEVE COOGAN) awaiting the birth of his son, all as servant Susannah (SHIRLEY HENDERSON) tends to his wife, Elizabeth (KEELEY HAWES) who's deep in the throes of labor, all as Dr. Slop (DYLAN MORAN) desires to use a new delivery device known as the forceps on her.
But all of this is just make-believe as Coogan, Brydon, Henderson, Hawes and Moran are really actors on the set attempting to film a version of "The Life and Opinions of Tristram Shandy, Gentleman," an 18th century novel known to most as un-filmable. But that hasn't deterred the cast or crew -- including director Mark (JEREMY NORTHAM), producer Simon (JAMES FLEET) and screenwriter Joe (IAN HART) -- from giving it their best shot.
When the dailies point out the low-budget approach and thus don't bode well for the film's success, the crew decides to reinsert the previously jettisoned love story, thus necessitating the hiring of Gillian Anderson (GILLIAN ANDERSON) to play Widow Wadman. As that fictional romantic element is rekindled, Steve must figure out and balance his own romantic longings for production assistant Jennie (NAOMIE HARRIS) as his girlfriend and mother of his child, Jenny (KELLY MACDONALD), arrives for a brief visit.