It's the late 1940s and 26-year-old divorcée Bettie Page (GRETCHEN MOL) has arrived in New York from Tennessee with hopes of making it big as an actress. But her vocational fate is set when she meets a New York cop and amateur photographer at Coney Island who sees her modeling abilities and suggests a new hair style that will soon become her signature look.
It's not long before she's modeling alongside Maxine (CARA SEYMOUR) in various stages of undress for a room full of photographers. That eventually leads her to Irving Klaw (CHRIS BAUER) and his sister Paula (LILI TAYLOR) who run a private outfit that caters to men with certain photographic fetishes.
Working with photographer John Willie (JARED HARRIS), she and Maxine end up posing in an increasingly popular series of bondage-related photos, all of which she manages to keep secret from her actor boyfriend Marvin (JONATHAN WOODWARD) who's similarly unaware of her posing for straight nude photos shot by former model Bunny Yeager (SARAH PAULSON).
Yet, they haven't escaped the attention of U.S. Senator Estes Kefauver (DAVID STRATHAIRN) and his committee that's investigating obscenity and pornography, specifically focusing on the kind of work Bettie does for Irving and Paula. As she continues her work and hopes to break into acting, Bettie must balance her growing fame with her religious upbringing.