It's sometime in the middle ages and Queen Isabel (RACHEL WEISZ) of Spain has sent one of her conquistadors, Tomas (HUGH JACKMAN), somewhere into Central America to find the Biblical Tree of Life. Legend has it that this tree from Eden possesses fruit that, if eaten, grants eternal life, something the Queen and Tomas want with each other.
In the present day, Tommy (HUGH JACKMAN) is a scientist working in a research lab for Dr. Lillian Guzetti (ELLEN BURSTYN), experimenting on primates trying to find cures for various diseases. His focus is intense since his wife, Izzi Creo (RACHEL WEISZ), is afflicted with a terminal disease, and he's getting ever closer to finding a cure, but time is running out.
Finally, there's Tom Creo (HUGH JACKMAN), some sort of futuristic man seemingly existing in some sort of bubble in outer space where he tends to what's presumably the Tree of Life and has recurring visions of both the Queen and Izzi. As the three stories become intertwined, the characters in them search for ways to prolong their lives.