Alex (ALLEN COVERT) is a 35-year-old video game tester at Brainasium, the game manufacturer behind the popular "Eternal Death Slayer" series. When he ends up getting evicted from his rental home, he tries staying with fellow tester Jeff (NICK SWARDSON), but that doesn't work out, and it doesn't seem wise to room with Dante (PETER DANTE), his drug dealer.
Accordingly, he begrudgingly moves in with his grandmother Lilly (DORIS ROBERTS) and her two older roommates, sarcastic Grace (SHIRLEY JONES) and prescription pill happy Bea (SHIRLEY KNIGHT), although he lies to Jeff and other testers Barry (JONAH HILL) and Kane (KELVIN YU) that their young, sex-crazed women.
Things look up at work when his new age boss Mr. Cheezle (KEVIN NEALON) hires Samantha (LINDA CARDELLINI) to oversee the latest release of "EDS" from legendary programmer and ultra-nerd J.P. (JOEL DAVID MOORE). As they work to meet their deadline and Alex finds himself falling for Samantha, he must put up with living with the trio of old ladies and their various idiosyncrasies.