It's 1966 and Don Haskins (JOSH LUCAS) has just accepted the head basketball coaching position at Texas Western University in El Paso. Moving into the men's dorm with his wife Mary (EMILY DESCHANEL) and their three young kids, Coach Haskins sets out with assistant coach Moe Iba (EVAN JONES) to recruit players, but the top-flight white ones don't want to play for him or the school.
Accordingly, they decide to recruit the best black players they can find around the country. That includes Bobby Joe Hill (DEREK LUKE), David Lattin (SCHIN A.S. KERR), Willie Worsley (SAM JONES III), Willie "Scoops" Cager (DAMAINE RADCLIFF), Nevil Shed (AL SHEARER), Harry Flournoy, Jr. (MECHAD BROOKS) and Orsten Artis (ALPHONSO McAULEY) who soon join white players Jerry Armstrong (AUSTIN NICHOLS), Togo Railey (KIP WEEKS), Dick Meyers (MITCH EAKINS), David Palacio (ALEJANDRO HERNANDEZ) and Louie Baudoin (JAMES OLIVARD).
Team trainer Ross More (RED WEST) informs Coach Haskins of the unofficial rules about the number of black players who can be on the court at the same time during a game, and others are more racist in their reaction to the situation. Yet, Coach Haskins moves ahead, trying to break the players of their showboating tendencies and instill a sense of teamwork among the players.
As the season proceeds and the team goes on an unlikely winning streak that might lead them into the playoffs where they could meet the Kentucky team led by legendary coach Adolph Rupp (JON VOIGHT), Coach Haskins tries to keep his team grounded and focused as they must deal with racism from both within and out.