It's 1956 in the Amazon basin of Ecuador and a fierce tribe of natives known as the Waodani is killing its own members at an alarming rate -- when not doing the same to rival tribes. Accordingly, a group of concerned missionaries, led by Nate Saint (CHAD ALLEN), wants to find the Waodani and, using the world of the Gospel, stop the chain of violence. But it won't be easy, as they're deep in the heart of the jungle. To make matters worse, their leader, Mincayani (LOUIE LEONARDO) -- who's witnessed, participated in and survived all of the violence throughout his life -- is wary of outsiders, particularly since his childhood friend Dayumae long ago disappeared with some of them.
Undeterred and operating from a base camp where his wife Marj (CARA STONER) and young son Stevie (CHASE ELLISON) live with other missionary families, Nate makes various flights over the jungle, eventually spotting the Waodani who think his plane is some form of large bee. By lowering various items down to them, the missionaries make contact with the natives. Stevie is concerned about his father's safety and so asks his aunt Rachel (SARA KATHRYN BAKKER), who's Dayumae's (CHRISTINA SOUZA) caretaker, for friendly words for his father to share with the Waodani to prove they pose no harm to them.
Unfortunately, that message comes too late and misinformation leads to a tragic attack where the Waodani kill various missionaries. Desirous of carrying on their mission, the families don't seek revenge, but instead continue to try to save the natives. Their message of peace doesn't sit well with Mincayani but does affect Kimo (JACK GUZMAN), a tribesman who's grown tired of the killings. From that point on, the missionaries hope to change the Waodani before it's too late.