Ted (voice of WILL FERRELL) is a guide at the Bloomsberry museum whose fervent attention to detail might bore the school children, but has caught the romantic attention of one of the school teachers, Maggie (voice of DREW BARRYMORE) who keeps bringing her students back for additional educational visits. Yet, that might end when museum owner Mr. Bloomsberry (voice of DICK VAN DYKE) states that they're going to have to close due to low attendance. That's good news to his adult son, Junior (voice of DAVID CROSS), who wants to build a parking lot where the museum stands, but Ted knows he has to do something to save the day.
Remembering that Bloomsberry was once an explorer, Ted reminds him of his quest long ago to find the Shrine of Zagawa. Bloomsberry's too old to take up such activities again, but thinks it's a grand idea for Ted. Outfitted in a yellow hat and suit that makes him look like a walking banana, the inexperienced archaeological explorer sets sail for Africa where, with the aide of local guide Edu (voice of MICHAEL CHINYAMURINDI), he thinks he's found the shrine.
Only it turns out to be just a few inches tall. Disappointed, Ted calls Bloomsberry and sends him a photo of the miniature monkey statuette. With nothing to give it any perspective, however, the owner thinks it's enormous and thus sets out to prepare the museum and the public for the "enormous" find. Unaware of that, Ted returns stateside, similarly oblivious to the fact that a playfully mischievous and curious monkey -- actually a chimp that he nicknamed George -- has stowed away on the ship.
Back in the big city, Ted sees Bloomsberry's promotions for the archaeological find, but is unable to tell his boss the truth or show him just how small the artifact really is. Besides, he's got his hands full with George who's just as capricious as before, meaning he has to keep him hidden from his apartment building's super, Ivan (voice of ED O'ROSS), as well as the snobby Miss Plushbottom (voice of JOAN PLOWRIGHT).
While trying to keep the "monkey" out of trouble, and with the aid of his inventor friend Clovis (voice of EUGENE LEVY), Ted tries to figure out how to save the day and not disappoint Mr. Bloomsberry, Maggie or the public who are eagerly awaiting his delivery of the African artifact.