It's 1824 Vienna, and famous and nearly deaf composer Ludwig van Beethoven (ED HARRIS) is in need of a new assistant to copy his sheet music for his latest symphony, since his longtime worker, Wenzel Schlemmer (RALPH RIACH), is now an old and sickly man. What he doesn't expect is musical composition student Anna Holtz (DIANE KRUGER) wanting that job. He initially dismisses her simply because she's a woman, but she quickly proves her talent and he likes the 23-year-old's veracity and spunk.
Her boyfriend, Martin Bauer (MATTHEW GOODE), an architect who's developed plans for a new city bridge, isn't particularly pleased since the composer has a reputation for being demanding and mean. Moreover, Mother Canisius (PHYLLIDA LAW), the nun who runs the convent where Anna lives, tries to warn her of what happens when dreams meet reality, especially since the young woman longs to write and conduct her own music, something unheard of in their day and age.
As Anna tries to get accustomed to Beethoven's ways and rules, she must also contend with his good-for-nothing adult nephew, Karl (JOE ANDERSON), who only uses his uncle for money to sustain his gambling habit and pay off his debts.
As the days count down toward the performance of Beethoven's first new symphony in a decade, Anna races to complete her work, all with hopes of impressing the composer enough that he might take a look at her own composition.