Novelist Catherine Tramell (SHARON STONE) is an American novelist living in London who has just crashed her sports car into a body of water. She manages to escape, but her soccer star passenger does not, arousing the suspicion of detective Roy Washburn (DAVID THEWLISS) who wonders if the novelist might be back to her old tricks. More than a decade ago, she was tied to a series of high profile murders in San Francisco that echoed the way people died in her latest work, all while she had a torrid affair with the detective investigating her.
Accordingly, psychoanalyst Dr. Michael Glass (DAVID MORRISSEY) is called in to make a professional call on her mindset before charges are made against her, something he discusses with his associate Milena Gardosh (CHARLOTTE RAMPLING). He decides Catherine is addicted to risk, an assessment that brings her back to him when charges are dropped against her. Although reluctant to take her on as a client, he finds her alluring and the two enter into a doctor/client relationship.
While Washburn tries to prove she's up to something, things become more complicated for Glass when reporter Adam Towers (HUGH DANCY) -- who just so happens to be dating Michael's ex-wife Denise (INDIRA VARMA) and reportedly is writing an article accusing the psychoanalyst of knowing one of his former clients was about to murder someone in the past -- ends up dead.
Despite having something of a relationship with psychopharmacologist Michelle Broadwin (FLORA MONTGOMERY), Glass finds himself drawn to Catherine despite knowing better. As the bodies start piling up, he must figure out how to deal with her, all as Washburn tries to convince him that she's using him in a dangerous game of sex, manipulation and murder.