In a rough, 1970s era Bronx neighborhood, Marcus (MARC JOHN JEFFERIES) is a young kid who doesn't know who fathered him with his drug-dealer mom Katrina (SERENA REEDER). When she's murdered, he ends up living with his grandparents (VIOLA DAVIS and SULLIVAN WALKER) and their large, extended family where there's little room for the orphan. With only hand-me downs to wear, Marcus takes to the only world he knows, dealing drugs.
Years later, Marcus (CURTIS "50 CENT" JACKSON) is still in the business, running with his crew that consists of Keryl (OMAR BENSON MILLER), Justice (TORY KITTLES) and Antwan (ASHLEY WALTERS), and dealing drugs for Majestic (ADEWALE AKINNUOYE-AGBAJE) who's just introduced them to the lucrative crystal meth market.
The highly competitive drug-dealing business, however, has run them afoul of a network of Columbian drug dealers, such as Raoul (WALTER ALZA), who aren't happy to have any competition. Accordingly, Majestic's boss, the godfather-type Levar (BILL DUKE), tries to establish a truce between the two warring factions. Yet, there's too much bad blood between them, and with Levar headed off for prison, Majestic takes over and only ratchets up the feud and related killings.
Having recently hooked back up with his childhood friend Charlene (JOY BRYANT), Marcus ends up in prison for his drug dealings. There, he meets another inmate, Bama (TERRENCE HOWARD), who not only saves his life, but also wants to become his manager and nurture the young man's natural talent for rap music.
When he gets out, Marcus wants to go straight and pursue his budding musical career, but he must then contend with Majestic who wants his number one dealer back on the streets and isn't pleased with the decision his former protégé has made.