Helen McCarter (KIMBERLY ELISE) would seem to have it all -- a huge house, an even bigger bank account, and a successful lawyer for a husband in the form of Charles (STEVE HARRIS). Yet, despite their appearances and 18-year marriage, he treats her like dirt in private and has fathered several children with Brenda (LISA MARCOS), his lover of the past several years.
Helen suspected but is still shocked by this, but not as much as when Charles kicks her out of the house and wants a divorce. Since she signed a pre-nup that leaves her nothing and he alienated her from her friends and family over the years, she has nowhere to go, much to the concern of Orlando (SHEMAR MOORE) who's been hired to transport her and her belongings wherever she wishes.
Upset over what's occurred, Helen sees the amiable Orlando like any other self-centered man and makes him leave. Desperate for a place to stay, she arrives on the ghetto doorstep of her gun-toting and highly opinionated grandmother Madea (TYLER PERRY) who allows her "dirty old man" brother Joe (TYLER PERRY) to live with her.
Madea forcibly confronts Charles in his home, wanting revenge on him, but ends up jailed and then under house arrest. Helen tries to get her life back in order, all while dealing with her conflicting feelings toward Charles who has his own problems when a former acquaintance, Jamison Jackson (GARY STURGIS), orders Charles to defend him in court regarding his arrest for shooting an undercover cop.
Those aren't the only family issues, as Helen's sister Debrah (TAMARA TAYLOR) is a junkie who's been kicked out by her husband, Brian (TYLER PERRY), for putting him and daughter Tiffany (TIFFANY EVANS) through so much. With the advice from her nursing home resident mom, Myrtle (CICELY TYSON), as well as Madea, Helen tries to figure out what to do, a choice that becomes more complicated when she starts falling for none other than Brian's friend, Orlando.