Saul Naumann (RICHARD GERE) is a religions studies professor in Oakland who's fascinated with the teachings and secrets of Kabbalah. Thus, when his sixth-grade daughter, Eliza (FLORA CROSS), seems to be channeling some sort of supernatural force that's allowing her to win at local spelling bees, he suddenly becomes enamored with helping her strengthen her gift that he believes is a pathway directly to God.
With his attention now focused solely on her for seemingly the first time in his life, he doesn't recognize his wife Miriam's (JULIETTE BINOCHE) growing depression and worsening mental instability. Still affected by a past traumatic event where she lost her parents in a car accident, she's progressively spending more of her time away from the house and lurking about others' homes, looking for something she thinks might fix everything in her life.
At the same time and now no longer the focus of his father's attention, older son Aaron (MAX MINGHELLA) begins to question his religious beliefs, a point that makes him vulnerable to the alluring Chali (KATE BOSWORTH), a Hare Krishna whose messages seem to mesh with what he's experiencing. As Eliza continues her winning ways through the various levels of spelling bees, her family unit begins to unravel as its various members search for meaning and answers in their lives.