Jessica Shepard (ASHLEY JUDD) is a beat cop who's just nabbed a murderer and been promoted to homicide detective. Partnered with veteran detective Mike Delmarco (ANDY GARCIA), she's immediately thrust into action when a body is found and appears to be the victim of a serial killer. What's more troubling for Jessica is that it's also a man with whom she had casual sex.
While others obviously think that's grounds to have her removed from the case, Police Commissioner John Mills (SAMUEL L. JACKSON) -- who essentially raised Jessica from a child following her parents' deaths -- says she'll stay due to no evidence against her, that it would ruin her career, and that her presence might lead to the killer's arrest. That doesn't sit well with other detectives, including Lieutenant Tong (RUSSELL WONG) while staff psychiatrist Dr. Melvin Frank (DAVID STRATHAIRN) tries to get inside Jessica's head to see what's really occurring there.
When a second murder takes place and the victim turns out to be another of her brief lovers, the suspicions about her begin to increase. She and others continue to wonder whether it's her doing the deed following alcohol-fueled blackouts, a deranged stranger, or even her former partner and boyfriend, Jimmy Schmidt (MARK PELLEGRINO), who won't accept that they're no longer a couple. When yet another past lover is murdered, Jessica tries to figure out what's going on before anyone else is killed.