Thanks to the work of the likes of Mr. Incredible (voice of CRAIG T. NELSON) and Elastigirl (voice of HOLLY HUNTER), the world is a better and safer place. Things seem good for such superheroes with young fans such as Buddy (voice of JASON LEE) wanting to be like them as well as Mr. Incredible and Elastigirl secretly getting married.
Yet, a spate of lawsuits filed by those who don't appreciate their work eventually puts them out of business with all given new identities, jobs and homes under a federal relocation program. Fifteen years later, Mr. Incredible is now insurance adjuster Bob Parr who, with Elastigirl -- now known as stay at home mom Helen -- are trying to keep a low profile and hope that their kids -- wallflower Violet (voice of SARAH VOWELL), the rambunctious Dash (voice of SPENCER FOX) and toddler Jack-Jack -- don't discover the truth despite their obviously inherited super powers.
Even so, Mr. Incredible is restless for his old life and thus sneaks off at night with Lucius, a.k.a. Frozone (voice of SAMUEL L. JACKSON) for some anonymous super heroics. That hasn't escaped the attention of Mirage (ELIZABETH PENA), a mysterious woman who hires Mr. Incredible to deal with some advanced robotic droids. His bigger concern, however, turns out to be Syndrome (voice of JASON LEE), a new super villain who controls the droids and is driven by a deep-seated agenda.
When Helen learns of Bob's actions, she's furious. Yet, with the aid of special costume designer Edna (voice of BRAD BIRD), Elastigirl sets out to rescue her hubby, unaware that the kids are in tow and ready for their first taste of superhero action.