Andy Washburn (JIMMY FALLON) is a New York City detective who isn't very good at his job, especially when it comes to driving. After yet another accident, his boss and former girlfriend, Lt. Marta Robbins (JENNIFER ESPOSITO), takes away his license and reassigns him as a beat cop. Thus, when he hears of a Manhattan bank robbery, he doesn't commandeer a car, but instead gets Belle Williams (QUEEN LATIFAH) to drive him there.
She's a former bike courier turned brand-new cabbie with a souped-up car and a desire to become a NASCAR driver one day. Accordingly, she has no problem keeping up with the exotic Vanessa (GISELE BÜNDCHEN) and her three Brazilian bank robber accomplices who dress as men to pull off their heists.
Andy and Belle get a look at the robbers, but don't manage to catch them, a point that doesn't impress Marta or newly arrived FBI Agent Mullins (CHRISTIAN KANE) who's now in charge of the case. He keeps Belle's cab as evidence, a point that doesn't sit well with her or her boyfriend Jesse (HENRY SIMMONS) when she doesn't show up for dinner with him.
The two then form an unlikely alliance where Belle needs Andy to get her cab back and he needs her to help catch the bank robbers and thus repair his credibility in the department and with Marta. With some help from Andy's lush mom (ANN-MARGRET), the two set out to accomplish both missions.