It's been more than three years since criminal ringleader Danny Ocean (GEORGE CLOONEY) and his team -- Rusty Ryan (BRAD PITT), Reuben Tishkoff (ELLIOT GOULD), Basher Tarr (DON CHEADLE), Livingston Dell (EDDIE JEMISON), Linus Caldwell (MATT DAMON), Frank Catton (BERNIE MAC), Yen (SHAOBO QIN), Saul Bloom (CARL REINER) and brothers Virgil (CASEY AFFLECK) and Turk (SCOTT CAAN) -- knocked off three Vegas faults and made off with more than $160 million.
All have gone their separate ways and pursued various endeavors, but the casinos' owner, Terry Benedict (ANDY GARCIA), has neither forgotten about nor forgiven them for their crime or for Danny getting his ex-wife, Tess (JULIA ROBERTS), to dump Terry in favor of getting back with Danny. For the past years, he and his henchmen have been tracking them down, and with a bit of insider information, he's managed to find them.
Given just two weeks to pay back all of the money -- with interest -- or else face Benedict's wrath, Danny and his team realize they're too hot to work in America, so they head off to Europe. There, they meet with a local contact, Matsui (ROBBIE COLTRANE), who arranges a small job for them with the deal being that if they're successful, they'll get a bigger one.
With time running out, they set out to do just that. Along the way, however, they must not only deal with Rusty's past relationship and recent reunion with Europol detective Isabel Lahiri (CATHERINE ZETA-JONES) who's soon hot on their trail, but also François Toulour (VINCENT CASSEL), a local criminal mastermind known as the Night Fox who wants to prove he's the world's best thief by besting their accomplishments.