Nate Johnson (CEDRIC THE ENTERTAINER) is an insurance agent who's had better times. Not only has he been separated from his wife, Dorothy (VANESSA WILLIAMS), for three months, but his teenage daughter, Nikki (SOLANGE KNOWLES), has also grown up too fast, son D.J. (BOW WOW) wants to be a rapper, and preteen Destiny (GABBY SOLEIL) is fixated on her imaginary dog.
Nevertheless, Nate is looking forward to driving from their Los Angeles neighborhood to their family reunion in Missouri. Of course, that not only means a road trip halfway across the country to see his mother, Glorietta (ALOMA WRIGHT), but also having to deal with his competitive brother, Mack (STEVE HARVEY), who's determined to win the family of the year award again this year. Then there's lecherous Uncle Earl (CEDRIC THE ENTERTAINER) who's always had his eye on Dorothy.
Despite the best intentions, one thing after another goes wrong on the trip, from picking up the wrong type of hitchhiker in the form of Chrishelle Rene Babineau (SHANNON ELIZABETH) to disregarding the law. As they continue on their quest, Nate hopes to arrive on time and hopefully spend some quality time with his family.