Samantha Mackenzie (KATIE HOLMES) is like every other teenager who's about to head off to college. That is, except for the fact that her father (MICHAEL KEATON) just so happens to be the President of the United States. Having grown up in the public eye, Sam knows how to handle herself, but is growing tired of being on the reelection treadmill, a point noted by her mom, Melanie (MARGARET COLIN), the First Lady.
With a bit of going away advice from her White House assistant, Liz Pappas (LELA ROCHON FUQUA), Sam travels across the country, but not without all of the First Daughter baggage that comes along with the position, including Secret Service agents Bock (MICHAEL MILHOAN) and Dylan (DWAYNE ADWAY) who are assigned to protect her.
Sam's new roommate, Mia Thompson (AMERIE), initially isn't pleased upon seeing her, but the two soon become fast friends, although all of the attention paid to Sam eventually gets on Mia's nerves. Sam also meets and falls for her R.A., James (MARC BLUCAS) who helps her elude the press and try to lead a normal, college life. Unfortunately, that includes some wild partying that makes the press, thus potentially endangering President Mackenzie's reelection bid. As the days pass and revelations occur, father and daughter try to come to grips with the situation and their evolving relationship.