It's 1973 and Erin (JESSICA BIEL), her boyfriend, Kemper (ERIC BALFOUR), and their friends Morgan (JONATHAN TUCKER) and Andy (MIKE VOGEL) are driving through a remote section of Texas. They've already picked up a hitchhiker, Pepper (Erica Leershen), along the way when they spot a young woman in obvious distress.
They can't get much out of her, but after she states that the others are dead, she commits suicide in their van. Unsure of what to do, the group stops and calls for the local sheriff. They end up apparently getting the run-around and are then told where to find him. As Erin and Kemper head off on foot and arrive at a desolate farmhouse, Sheriff Hoyt (R. LEE ERMEY) shows up where the others are awaiting.
With a dark sense of humor, he investigates the suicide scene, but doesn't seem too intent on enforcing the law as they would expect. He eventually turns rather mean and sadistic toward them, but that's not the worse they'll face. For a homicidal madman, Thomas "Leatherface" Hewitt (ANDREW BRYNIARSKI), is after them, chainsaw in hand.
From that point on, the group must do what they can to survive and avoid becoming part of the killer's collection of bodies and body parts.