Elizabeth "Bitsey" Bloom (KATE WINSLET) is a magazine news reporter who's been called upon to interview death row inmate David Gale (KEVIN SPACEY). Set to die via lethal injection at the end of the week, the former philosophy professor and his attorney, Braxton Belyeu (LEON RIPPY), have personally selected Bitsey for what will amount to three, two-hour sessions.
Considering that he's never given an interview regarding his conviction of raping and murdering his colleague and fellow anti-death penalty advocate, Constance Harraway (LAURA LINNEY), Bitsey takes the assignment. She's not happy, however, that an intern, Zack Stemmons (GABRIEL MANN), is sent along with her, but already has her mind set that Gale is guilty and deserves to die.
When she meets him and he recounts his story, however, she soon begins to change her mind. Over the course of three days and through a series of flashbacks, Gale tells her about his troubled marriage to Sharon (ELIZABETH GAST) but loving relationship with their son, Jamie (NOAH TRUESDALE). She also learns of his drinking problem and a brief and drunken tryst with one of his students, Berlin (RHONA MITRA). That then turned into an allegation of rape which sent his life into a downward spiral, eventually leading to him being charged with the crimes against Constance.
With time running out and a shadowy figure, Dusty Wright (MATT CRAVEN), trailing their every move, Bitsey and Zack must figure out the truth about what occurred to Constance, whether Gale was involved and do so all before he's executed.