April Burns (KATIE HOLMES) is a young woman trying to get her life back on track. One way of doing that is by making amends with her younger siblings, Beth (ALISON PILL) and Timmy (JOHN GALLAGHER, JR.), dad Jim (OLIVER PLATT) and especially her mom, Joy (PATRICIA CLARKSON). Accordingly, she's invited all of them to her Lower East Side apartment for Thanksgiving.
April's live-in boyfriend, Bobby (DEREK LUKE), thinks it's a great idea and asks her if she needs help preparing the feast. She says no and he heads off to meet an associate, Latrell (SISQO), for some initially undisclosed reason.
It's only then that April discovers that their oven no longer works. Frantic to get the turkey cooked, she visits various neighbors including Wayne (SEAN HAYES), an oddball type with a new oven, and Eugene (ISIAH WHITLOCK, JR.) and Evette (LILLIAS WHITE) who help her out, but can only give her bird half the time it needs.
With her family en route with Grandma Dottie (ALICE DRUMMOND), and everyone trying to cope with Joy's terminal illness, April races to get everything ready before they arrive.