It's London 1984 and Sarah Jordan (ANGELINA JOLIE) is an American living a pampered life with her British husband, Elliott Hauser (NOAH EMMERICH). At a swanky reception hosted by Elliot's father, renegade doctor Nick Callahan (CLIVE OWEN) crashes the event, protesting the cut in funds for the relief camps where he works in Africa.
Sarah is so taken with his dramatic plea that she decides to visit his latest camp in Ethiopia. There, she meets Nick's cohorts, including his calmer and more reasonable associate, Henry Bauford (LINUS ROACHE), but has an eye-opening experience regarding the conditions of those in their camp.
Although her stint there is short, she becomes more involved in humanitarian aid via the U.N., but can't forget Nick and his work. That eventually leads to her traveling to other hot spots around the world where Nick and his team are working.
Yet, when his involvement with covert CIA operative Jan Steiger (YORICK VAN WAGENINGEN) seems to have gotten Nick into trouble, Sarah - who's now fallen for him - sets out - with the help of her TV anchor sister, Charlotte (TERI POLO) -- to find him.