Pistachio Disguisey (DANA CARVEY) is a young and amiable man with a knack for mimicry who works as a waiter at the Italian restaurant run by his father, Frabbrizio (JAMES BROLIN). Although his imitations of people sometimes get out of hand, he's a good-natured sort who befriends Barney Baker (AUSTIN WOLFF), a local klutzy boy, and hopes that one day he might marry Sophia (MARIA CANALS), a woman with a large posterior that reminds him of his mother (EDIE McCLURG).
Unbeknownst to Pistachio, his father is a former master of disguises who decades ago foiled the attempts of criminal mastermind Devlin Bowman (BRENT SPINER) and sent him to prison for twenty years. Now wanting his revenge, Bowman kidnaps Pistachio's parents with the goal of using Frabbrizio to steal the world's most precious treasures while disguised as famous people.
Unsure of what to do, Pistachio receives a visit by his grandfather (HAROLD GOULD) who's also a former master of disguises. Grandpa Disguisey informs Pistachio of his heritage and then sets out to train the young man in the way of disguises as well as "Energico," a channeling force that will allow him to transform completely into any number of identities.
With the aid of his assistant, Barney's mother Jennifer (JENNIFER ESPOSITO), Pistachio sets out to rescue his parents from Bowman's clutches, all while using a wide variety of disguises to do so.