Dave (BARRY WATSON), Adam (MICHAEL ROSENBAUM) and Doofer (HARLAND WILLIAMS) are three guys who enjoy living in the Kappa Omicron Kappa house and throwing wild and sexist parties that irritate Leah (MELISSA SAGEMILLER), an outspoken feminist and head of the local chapter of Delta Omicron Gamma.
Yet, when Spence (BRAD BEYER), the KOK president, announces that the money the fraternity has been collecting for an important alumni cruise has been stolen by the three, they're immediately chased from the premises. When they realize that Spence was the only other person with the combination to the safe in their room and that he must have been caught on their hidden, motion-activated video camera, Dave, Adam and Doofer decide they must retrieve the tape to prove their innocence.
The only problem is that no one, including Adam's little fraternity brother, Jimmy (TONY DENMAN), will let them in. Accordingly, they show up at the next party dressed in drag and going by the names of Daisy, Adina and Roberta. Not surprisingly, their less than attractive looks immediately get them thrown from the house and to Leah's feet who's outside protesting.
Drawn in by her offer of free food as well as room and board if they pledge DOG, the three decide they can live there as women while they plot how to get their hands on that videotape. While there, they meet other sorority sisters including Patty (KATHRYN STOCKWOOD), who thinks she's a freak because of her height, Katie (HEATHER MATARAZZO) who has a rather loud speaking voice, and Frederique (YVONNE SCIO), a rather hairy French student.
As the men try to keep up their ruse, they soon learn the trials and tribulation of being a less than attractive woman at the college, all while Dave begins to fall for Leah who sees him as a compassionate female friend and possible lover. With the date of the important alumni cruise nearing, the three men in drag try to deal with their femininity while also attempting to clear their names of theft.