Josie McCoy (RACHAEL LEIGH COOK), Melody Valentine (TARA REID) and Valerie Brown (ROSARIO DAWSON) are three young women in Riverdale who are hoping to take their garage band, The Pussycats, to bigger and better things. Unfortunately, their manager, Alexander Cabot (PAULO COSTANZO), can only get them gigs playing in bowling alleys and most everyone, including his sister Alexandra (MISSI PYLE) and many of the other local girls, don't give them or their music any respect.
That changes when record manager Wyatt Frame (ALAN CUMMING) stumbles across them while looking for a new act after recently dumping his boy band, Dujour, when they started asking too many questions about their music. Although he's never seen them play nor heard their songs, Wyatt - who's under orders by Mega Records CEO Fiona (PARKER POSEY) to find a replacement band as soon as possible - signs them up and the girls and their songs are suddenly shot to the top of the charts thanks to Mega Records's marketing prowess.
In doing so, Wyatt decides that Josie, the lead singer, should be the band's leader, a point that doesn't sit well with Val, the bass player, but makes little difference to Mel, the ditsy drummer. Soon dissension begins to set in within the band, and Josie discovers that she no longer has time for her hometown friend and potential boyfriend, Alan M. (GABRIEL MANN).
The girls eventually realize, however, that Fiona and Wyatt have been inserting subliminal messages in their songs - in conjunction with the U.S. Government - to stimulate the economy by having their audience buy their records along with any other products or fads they decide to introduce. From that point on, the girls must contend with their new feelings for one another, their music, and the evil recording industry that wants to silence them now that the girls are wise to their marketing secret.