As noisy Bonfire Night celebrations continue over a long autumnal weekend in London, various members of a large family get on with their everyday lives. Bill (JACK SHEPHERD) and Eileen (KIKA MARKHAM) are the middle-aged parents stranded in a loveless marriage. Their daughter Debbie (SHIRLEY HENDERSON) is a hairdresser who's raising her son, Jack (PETER MARFLEET), and is separated from her worthless husband, Dan (IAN HART).
Her sister, Nadia (GINA MCKEE), is a café waitress who's searching for love and going on many blind dates stemming from her ad in the personals, while their other sister, Molly (MOLLY PARKER), is nine months pregnant and dealing with the baby's father, Eddie (JOHN SIMM), who's suddenly decided to quit his job. Then there's their brother, Darren (ENZO CILENTI), whose estrangement from his parents has everyone concerned.
As the weekend progresses, the various family members must come to grips with newfound realizations about themselves, as well as their relationships with family member and others.