Joel Campbell (JAMES SPADER) is a burned-out FBI agent who's moved from Los Angeles to Chicago hoping to erase the psychological trauma and memories of his time spent hunting down psychotic killers. As such, he's seeing Dr. Polly Peilman (MARISA TOMEI), a young psychologist who's trying to help him work out his problems and relieve his migraine headaches and dependency on the prescription drugs that help get him from day to day.
When a young woman is murdered in his apartment building and he then finds that someone mailed her picture to him days before, Campbell suddenly realizes that a nemesis of his from the past, David Allen Griffin (KEANU REEVES), has apparently followed him to the windy city. It seems that Griffin's serial murder spree isn't enough for him, and thus he begins taunting Campbell by sending him photos of his future victims, informing the agent that he only has one day to save her.
With the help of detectives Hollis Mackey (CHRIS ELLIS) and Mitch Casper (ROBERT CICCHINI), Campbell then sets out to find and stop Griffin before he strikes again, all while realizing that the killer has sucked him into a manipulative game of cat and mouse.